Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

26.7K
Overview
26.7K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.7K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.7K
Hypersensitivities01:30

Hypersensitivities

7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

293
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
293
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

223
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
223

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Allergic rhinitis in the elderly. In collaboration with ARIA guidelines.

The journal of allergy and clinical immunology. In practice·2026
Same authorSame journal

Skin symptoms during the pollen seasons and their association with the severity of seasonal allergic rhinitis in Yamanashi, Japan.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same author

Estimating Work-Related Indirect Costs in Allergic Rhinitis and Asthma Using a Daily Combined Symptom-Medication Score: A MASK-air Study in Collaboration With the EAACI Methodology Committee.

The journal of allergy and clinical immunology. In practice·2026
Same author

Polystyrene nanoplastics induce mitochondrial dysfunction and stress responses in human PBMCs.

Ecotoxicology and environmental safety·2026
Same author

Leveraging Artificial Intelligence in Allergy, Asthma, and Immunology With Environmental Exposures.

Allergy·2026
Same author

Sublingual allergen immunotherapy in immunosuppressed rheumatoid arthritis patients: Safety and clinical outcomes.

The journal of allergy and clinical immunology. Global·2026

Related Experiment Video

Updated: May 5, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

11.3K

Allergen immunotherapy and tolerance.

Tomokazu Matsuoka1, Mohamed H Shamji, Stephen R Durham

  • 1Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Imperial College London, London, United Kingdom.

Allergology International : Official Journal of the Japanese Society of Allergology
|November 28, 2013
PubMed
Summary
This summary is machine-generated.

Allergen-specific immunotherapy (AIT) reduces allergy symptoms and drug use, inducing long-lasting tolerance. This involves modulating immune cells and promoting regulatory T cells for sustained relief.

More Related Videos

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.9K
Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

22.5K

Related Experiment Videos

Last Updated: May 5, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

11.3K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.9K
Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

22.5K

Area of Science:

  • Immunology
  • Allergy Research
  • Clinical Medicine

Background:

  • Allergen-specific immunotherapy (AIT) offers sustained relief from allergy symptoms.
  • AIT induces clinical and immunological tolerance, persisting years after treatment cessation.
  • Understanding AIT's mechanisms is crucial for optimizing allergy treatments.

Purpose of the Study:

  • To elucidate the immunological mechanisms underlying successful AIT.
  • To identify key cellular and molecular changes associated with AIT-induced tolerance.
  • To explore how AIT modulates innate and adaptive immune responses.

Main Methods:

  • Analysis of innate effector cell suppression (mast cells, basophils).
  • Assessment of T helper 2 (Th2) and B cell responses during AIT.
  • Identification of regulatory T cell populations (IL-10+ Tregs, TGF-β+ Tregs, FoxP3+ memory T regs).
  • Evaluation of B cell switching to IgG (especially IgG4) and regulatory B cells.
  • Investigation of dendritic cell subset alterations.
  • Examination of T cell proliferation, immune deviation (Th2 to Th1), apoptosis, and co-stimulation failure.

Main Results:

  • AIT suppresses innate effector cells and modulates Th2 and IgE+ B cell responses.
  • Tolerance is linked to induction of allergen-specific T regulatory cells (Tregs).
  • B cells shift towards IgG4 production, inhibiting IgE-mediated reactions.
  • IL-10+ B regulatory cells and altered dendritic cells are induced.
  • AIT leads to Treg induction, suppressed T cell proliferation, and Th1-biased immune deviation.
  • Alternative tolerance mechanisms include Th2 cell apoptosis and T cell anergy.

Conclusions:

  • AIT successfully induces long-term tolerance by orchestrating complex immune system changes.
  • Key mechanisms include Treg induction, B cell switching, and immune deviation towards Th1 responses.
  • These findings provide a foundation for refining AIT strategies and improving patient outcomes in allergy management.