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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Adaptive Mechanisms in Cancer Cells02:53

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Mitogens and the Cell Cycle02:38

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Related Experiment Video

Updated: May 5, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Angiogenesis and melanoma.

Domenico Ribatti1, Tiziana Annese, Vito Longo

  • 1Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari, Italy. ribatti@anatomia.uniba.it.

Cancers
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Summary
This summary is machine-generated.

Tumor progression involves angiogenesis, the growth of new blood vessels. This review explores the link between angiogenesis and human melanoma, including antiangiogenic therapies.

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Area of Science:

  • Oncology
  • Vascular Biology
  • Dermatology

Background:

  • Angiogenesis, or new blood vessel formation, is crucial for pathological conditions like tumors.
  • Tumor progression critically involves transitioning from avascular to vascular phases.
  • Neoplastic cells release growth factors that stimulate host blood vessel growth, driving tumor angiogenesis.

Purpose of the Study:

  • To review the relationship between angiogenesis and human melanoma progression.
  • To describe recent applications of antiangiogenic agents in melanoma treatment.

Main Methods:

  • Literature review of studies on angiogenesis and melanoma.
  • Summary of research on antiangiogenic agents' effects on melanoma progression.

Main Results:

  • Angiogenesis is a key factor in melanoma development and progression.
  • Antiangiogenic agents show potential in interfering with melanoma progression.

Conclusions:

  • Understanding the role of angiogenesis is vital for melanoma treatment strategies.
  • Targeting angiogenesis offers a promising therapeutic avenue for human melanoma.