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Published on: August 23, 2024
Haematological cancer: Richter's transformation in CLL-a distinct lymphoma
1Department of Leukemia, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA.
Abstract:
A landmark study has delineated and identified the genetic pathways that drive the natural course of chronic lymphocytic leukaemia (CLL) B cells into Richter’s transformation. CLL-related Richter’s transformation is a distinct lymphoma, and poses various questions about B-cell ontogeny and relevance of B cell receptor signalling inhibitors.
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