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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

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Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
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Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

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Circulating tumor cells, enumeration and beyond.

Jian-Mei Hou1, Matthew Krebs, Tim Ward

  • 1Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. cdive@picr.man.ac.uk.

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|November 28, 2013
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Summary
This summary is machine-generated.

Detecting circulating tumor cells (CTCs) aids cancer prognosis and treatment decisions. Current methods struggle to isolate these rare cells, hindering comprehensive analysis of tumor biology and metastasis.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Circulating tumor cells (CTCs) are crucial biomarkers for cancer prognosis and treatment selection in various cancers.
  • CTCs offer real-time insights into tumor biology and metastasis, acting as a 'virtual biopsy'.

Purpose of the Study:

  • To review current methods for CTC detection and enumeration.
  • To focus on molecular characterization, heterogeneity, and purification of CTCs.
  • To explore future approaches for comprehensive CTC biology dissection.

Main Methods:

  • Review of existing literature on CTC detection and enumeration technologies.
  • Analysis of methods for molecular profiling and characterization of CTCs.
  • Discussion of challenges and advancements in CTC purification techniques.

Main Results:

  • CTC detection and enumeration are clinically valuable for prognosis in breast, colorectal, and prostate cancers.
  • Emerging studies highlight CTCs' role in providing pharmacodynamic information for therapy guidance.
  • Current technologies often enrich rather than purify CTCs, posing a 'needle in the haystack' challenge for molecular analysis.

Conclusions:

  • Despite challenges in purification, CTCs hold significant potential for understanding tumor biology and metastasis.
  • Advancements in CTC characterization and purification are essential for comprehensive dissection of CTC biology.
  • Future research should focus on developing technologies for pure CTC isolation and detailed molecular profiling.