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Glutamine in the intensive care unit.

Luc Cynober1, Jean-Pascal De Bandt

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Recent studies on glutamine supplementation in critically ill patients show conflicting results. Precise indications for its use in parenteral and enteral nutrition require further determination.

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Area of Science:

  • Clinical Nutrition
  • Critical Care Medicine
  • Nutritional Support

Background:

  • Glutamine supplementation is considered beneficial for acutely injured patients.
  • Parenteral and enteral nutrition are common in critical care settings.

Purpose of the Study:

  • To review recent literature (2011-2013) on glutamine supplementation in critically ill patients.
  • To identify factors contributing to conflicting research outcomes.

Main Methods:

  • Literature review of studies published between 2011 and 2013.
  • Analysis of prospective, multicenter, and smaller clinical trials.

Main Results:

  • Recent trials on glutamine supplementation have yielded conflicting results.
  • Patient heterogeneity (injury severity, age, nutritional status) and challenges in identifying appropriate candidates may explain discrepancies.

Conclusions:

  • While glutamine is recognized as beneficial, recent conflicting data necessitate a more precise definition of its indications.
  • Further research is needed to clarify optimal use in 'real-life' or severe critical illness scenarios.