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Probiotics and atopic dermatitis in children.
Fabio Meneghin1, Valentina Fabiano, Chiara Mameli
1Department of Pediatrics, Luigi Sacco Hospital, Università degli Studi di Milano, Via GB Grassi 74, 20157 Milan, Italy. meneghin.fabio@hsacco.it.
Pharmaceuticals (Basel, Switzerland)
|November 28, 2013
Summary
Probiotic supplementation shows promise for treating atopic eczema in children, but more research is needed to confirm its effectiveness as a preventative strategy. The benefits depend on various factors like probiotic type and dosage.
Area of Science:
- Pediatric Allergy and Immunology
- Microbiome Research
- Immunology
Background:
- Growing interest in probiotics for preventing and treating childhood atopic diseases.
- Probiotics, live microorganisms like Lactobacilli and Bifidobacteria, may modulate gut microbiota and immune responses.
- Intestinal microflora differs between atopic and healthy children, suggesting a role for probiotics.
Purpose of the Study:
- To evaluate the potential impact of probiotic supplementation on the prevention and treatment of atopic dermatitis (eczema) in children.
- To explore the immunomodulatory effects of probiotics on Th1/Th2 balance in early immune development.
- To synthesize current evidence on probiotic efficacy in managing allergic eczema.
Main Methods:
- Review of epidemiological data and literature on probiotic use in atopic diseases.
- Analysis of studies investigating probiotic supplementation for atopic dermatitis prevention and treatment.
- Consideration of factors influencing probiotic efficacy, including bacterial strain, dosage, and host characteristics.
Main Results:
- Some studies report clinical improvement in immunoglobulin (Ig)E-sensitized eczema with probiotic supplementation.
- Therapeutic effects of probiotics on atopic dermatitis appear encouraging in certain contexts.
- Results regarding the usefulness of probiotics as a prevention strategy remain inconclusive.
Conclusions:
- Probiotics may offer benefits in treating atopic dermatitis, but conclusive evidence for prevention is lacking.
- The efficacy of probiotic therapy is influenced by numerous factors, including specific bacterial strains, dosage, and host-related elements.
- Further rigorous studies are required to definitively establish the role of probiotics in the management of allergic eczema.
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