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A systems neuroscience approach to the pathophysiology of pediatric mood and anxiety disorders

Wan-Ling Tseng1, Ellen Leibenluft, Melissa A Brotman

  • 1Department of Health and Human Services, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, 15K North Drive, MSC 2670, Bethesda, MD, 20892, USA, wan-ling.tseng@nih.gov.

Current Topics in Behavioral Neurosciences
|November 28, 2013
PubMed

Insights

Pediatric mood and anxiety disorders involve emotional dysregulation linked to brain abnormalities. Research highlights neural mechanisms and potential treatments for these conditions in children.

Area of Science:

  • Neuroscience
  • Child Psychology
  • Developmental Psychiatry

Background:

  • Emotional dysregulation is a key symptom in pediatric mood and anxiety disorders.
  • These disorders are increasingly understood to involve alterations in the developing brain's structure and function.

Purpose of the Study:

  • To review recent behavioral and functional magnetic resonance imaging (fMRI) research on pediatric mood and anxiety disorders.
  • To focus on the neural mechanisms underlying these conditions.
  • To explore the relationship between neural findings, behavioral outcomes, and potential treatments.

Main Methods:

  • Review of recent behavioral studies.
  • Analysis of functional magnetic resonance imaging (fMRI) research.
  • Synthesis of findings on neural mechanisms in pediatric mood and anxiety disorders.

Main Results:

  • Abnormalities in brain function and structure are implicated in pediatric mood and anxiety disorders.
  • Neural findings correlate with observed behavioral patterns.
  • Emerging evidence points to potential novel treatment targets.

Conclusions:

  • Understanding the neural underpinnings is crucial for diagnosing and treating pediatric mood and anxiety disorders.
  • Future research should continue to integrate neural and behavioral data to refine treatment strategies.
  • Further investigation is needed to fully elucidate the developmental trajectory of these disorders and their neural correlates.

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