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Beyond white light endoscopy: the role of optical biopsy in inflammatory bowel disease

Julia Liu1, Aldona Dlugosz, Helmut Neumann

  • 1Julia Liu, Division of Gastroenterology, the Centre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Alberta T6G 2X8, Canada.

World Journal of Gastroenterology
|November 28, 2013
PubMed

In this review, we will discuss the use of two optical biopsy modalities in inflammatory bowel disease (IBD). The two techniques reviewed here are confocal laser endomicroscopy and endocytoscopy. We will describe the technical performance of the procedure, discuss the clinical indications for optical biopsy in IBD, and highlight active research areas with respect to the pathogenesis of IBD. Clinical indications for optical biopsies in IBD include assessment of mucosal inflammation, dysplasia detection and evaluation of cell shedding for disease relapse. Research application in the area of barrier dysfunction will also be discussed.

Keywords:
Barrier functionConfocal endomicroscopyDisease relapseDysplasiaEndocytoscopyMucosal healingMucosal inflammationOptical biopsy

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