Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Phase-tuned modulation during reward expectancy in human anterior insular cortex.

Communications biology·2026

Same author

Competition Between Memory Updating and Differentiation Emerges From Intrinsic Network Dynamics.

Neural computation·2026

Same author

Cerebellar Transcranial Alternating Current Stimulation in the Theta Band Prevents Recall of the Initial Fear Association After Extinction Training.

Human brain mapping·2026

Same author

Pituitary adenomas associated with hydrocephalus: clinical characteristics, risk stratification, and clinical management.

Journal of neuro-oncology·2026

Same author

Accounting for sensitivity of latent learning to behavioral statistics with successor representations.

PLoS computational biology·2026

Same author

Exploring the role and therapeutic potential of RNA N6-methyladenosine modification in abortion disease pathology: a comprehensive review.

Frontiers in genetics·2026

Same journal

Learning under constraints: a theoretical framework for comparing resource-constrained learning in biological and artificial systems.

Frontiers in computational neuroscience·2026

Same journal

MsGCN: a multi-stream graph convolutional network for multiband PLV graph fusion in EEG-based biometric identification.

Frontiers in computational neuroscience·2026

Same journal

AI-driven neuroanalytic modeling for mental health: multichannel CNN-based autism spectrum disorder detection via facial pattern analysis.

Frontiers in computational neuroscience·2026

Same journal

Modeling multiscale neural dynamics for EEG-based emotion recognition using an attentive wavelet-transformer framework.

Frontiers in computational neuroscience·2026

Same journal

New directions for complex systems in contemporary neuroscience: a morphodynamic and emergent function approach.

Frontiers in computational neuroscience·2026

Same journal

NMDA receptor kinetics drive distinct routes to chaotic firing in pyramidal neurons.

Frontiers in computational neuroscience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 5, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

A computational model for preplay in the hippocampus.

Amir H Azizi¹, Laurenz Wiskott, Sen Cheng

¹Mercator Research Group "Structure of Memory," Department of Psychology, Ruhr-University Bochum Bochum, Germany.

Frontiers in Computational Neuroscience

|November 28, 2013

Summary

This summary is machine-generated.

The hippocampus generates neural sequences intrinsically, even before experiencing an environment. This offline sequential activity (OSA) can predict future place fields, suggesting internal network organization rather than external input.

Keywords:

continuous attractor neural networks multi-chart structure preplay sequential activity spike-frequency-adaptation

More Related Videos

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Published on: March 27, 2015

Related Experiment Videos

Last Updated: May 5, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Published on: March 27, 2015

Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

The hippocampus generates sequential neural activity during offline states, correlating with place field sequences.
This offline sequential activity (OSA) phenomenon, observed before an animal enters a novel environment (preplay), suggests intrinsic hippocampal network generation.
Previous models explained preplay using single-chart representations, but the hippocampus's capacity for global remapping (multiple charts) posed a challenge.

Purpose of the Study:

To investigate whether a hippocampal network model with multiple simultaneous spatial representations (charts) can account for the preplay phenomenon.
To explore the mechanisms by which intrinsic network activity could generate sequential neural patterns predictive of future environments.

Main Methods:

Developed a computational model of a hippocampal network capable of representing multiple spatial charts.
Simulated the network with random inputs to observe the generation of sequential activity within each chart.
Analyzed correlations between generated OSA and place fields within existing and novel charts.

Main Results:

The model successfully generated correlated OSA within each chart when driven by random inputs.
Significant correlations were observed between OSA and place fields in novel charts, often due to random correlations between chart orderings.
The findings support two potential mechanisms for preplay: re-use of existing charts or formation of new charts.

Conclusions:

A hippocampal network model with multiple charts can intrinsically generate sequential activity consistent with preplay.
Preplay may arise from either the reuse of established spatial maps or the emergence of new ones within the hippocampal network.
These findings offer insights into the neural basis of spatial memory formation and prediction.