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Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Contact-dependent Signaling01:19

Contact-dependent Signaling

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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
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Antigen Processing Pathways01:31

Antigen Processing Pathways

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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
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Human plasmacytoid dendritic cells: from molecules to intercellular communication network.

Till S M Manuel Mathan1, Carl G Figdor, Sonja I Buschow

  • 1Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre , Nijmegen , Netherlands.

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|November 28, 2013
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Plasmacytoid dendritic cells (pDCs) are crucial for antiviral immunity and cancer immunotherapy. This review explores their surface proteins, revealing new insights into immune cell communication and pDC-driven responses.

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Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols
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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Plasmacytoid dendritic cells (pDCs) are key immune cells.
  • They secrete Type I interferon, crucial for antiviral responses.
  • pDCs are also effective antigen-presenting cells, relevant for cancer immunotherapy.

Purpose of the Study:

  • To highlight cell surface proteins on human pDCs.
  • To explore how these proteins mediate communication with other immune cells.
  • To discuss the implications for pDC-driven immune responses.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of cell surface protein expression in human pDCs.
  • Discussion of functional implications based on published data.

Main Results:

  • Identification of specific cell surface proteins on human pDCs.
  • Elucidation of potential roles in immune cell interactions.
  • Understanding of how these proteins influence pDC functions.

Conclusions:

  • pDC functions extend beyond IFN secretion and antigen presentation.
  • Cell surface proteins are critical mediators of pDC interactions.
  • Targeting these molecules may enhance pDC-based immunotherapies.