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Cervicothoracic multisegmental transpinal evoked potentials in humans.

Jonathan Einhorn1, Alan Li, Royi Hazan

  • 1The Graduate Center, City University of New York, New York, New York, United States of America.

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Summary
This summary is machine-generated.

Transcutaneous electric stimulation of the spine (tsESS) can modulate spinal reflexes. This study found tsESS facilitated arm TEPs and depressed the FCR H-reflex, suggesting therapeutic potential for neurological disorders.

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Area of Science:

  • Neuroscience
  • Human Physiology
  • Rehabilitation Medicine

Background:

  • Spinal reflex excitability is implicated in various neurological disorders.
  • Non-invasive neuromodulation techniques are sought for therapeutic interventions.
  • Transcutaneous electric stimulation of the spine (tsESS) offers a potential method for modulating spinal circuits.

Purpose of the Study:

  • To characterize the neurophysiological properties of transpinal evoked potentials (TEPs) using tsESS.
  • To investigate the effects of tsESS on TEPs amplitude following median nerve stimulation.
  • To examine the influence of tsESS on the flexor carpi radialis (FCR) H-reflex.

Main Methods:

  • TEPs were recorded from arm muscles in healthy subjects following tsESS at various frequencies and double pulses.
  • TEPs were also assessed following median nerve stimulation at different conditioning-test intervals.
  • The FCR H-reflex was evoked and conditioned by tsESS using double median nerve pulses.

Main Results:

  • Arm TEP amplitudes were generally maintained at low tsESS frequencies and with double pulses.
  • Ipsilateral median nerve stimulation facilitated both ipsilateral and contralateral arm TEPs.
  • The FCR H-reflex was depressed by double pulses and tsESS across various conditioning-test intervals.

Conclusions:

  • Non-invasive tsESS demonstrates potential as a therapeutic tool for reducing spinal reflex hyper-excitability.
  • Combining tsESS with peripheral nerve stimulation may enhance spinal output modulation.
  • These findings support tsESS for managing neurological conditions characterized by altered spinal reflexes.