Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcytosis of IgG01:15

Transcytosis of IgG

3.4K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.4K
Genomics02:02

Genomics

35.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.6K
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

1.9K
Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
1.9K
Gene Conversion02:08

Gene Conversion

2.3K
2.3K
Gene Conversion02:08

Gene Conversion

9.2K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
9.2K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

13.4K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating real-world deployment of an HL7-CDA-aligned LLM for ICD-10-CM coding.

NPJ digital medicine·2026
Same author

Attention-PestNet: hierarchical scaled dot-product attention for insect pest detection.

Plant methods·2025
Same author

Leveraging large language models for the deidentification and temporal normalization of sensitive health information in electronic health records.

NPJ digital medicine·2025
Same author

Blind Testing Method to Validate the Efficiency of ICD-10-CM Artificial Intelligence Coding Modules.

Studies in health technology and informatics·2025
Same author

Hierarchical Temporal Attention Networks for Cancer Registry Abstraction: Leveraging Longitudinal Clinical Data With Interpretability.

IEEE journal of biomedical and health informatics·2025
Same author

Enhancing biomedical relation extraction through data-centric and preprocessing-robust ensemble learning approach.

Database : the journal of biological databases and curation·2025

Related Experiment Video

Updated: May 5, 2026

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

13.8K

Collective instance-level gene normalization on the IGN corpus.

Hong-Jie Dai1, Johnny Chi-Yang Wu, Richard Tzong-Han Tsai

  • 1Graduate Institute of BioMedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, R.O.C.

Plos One
|November 28, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a new method for gene normalization (GN), accurately linking gene mentions to database IDs. The approach improves gene recognition and normalization, enhancing biomedical literature analysis.

More Related Videos

Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing
10:44

Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing

Published on: March 23, 2022

4.1K
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

23.7K

Related Experiment Videos

Last Updated: May 5, 2026

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

13.8K
Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing
10:44

Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing

Published on: March 23, 2022

4.1K
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

23.7K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Gene mentions in biomedical literature are crucial but ambiguous.
  • Existing gene recognition methods lack sufficient accuracy for direct use.
  • Gene normalization (GN) links gene mentions to database IDs, but instance-level approaches are underdeveloped.

Purpose of the Study:

  • To develop and evaluate an instance-level gene normalization (GN) approach.
  • To release the first instance-level gene normalization (IGN) corpus for research.
  • To improve the accuracy of gene mention recognition and normalization in biomedical texts.

Main Methods:

  • Developed a collective instance-level GN approach utilizing contextual, relational, and full-text section information.
  • Created and utilized the first instance-level gene normalization (IGN) corpus in BioC format.
  • Incorporated species information, co-reference chains, and name/abbreviation pairs into the model.

Main Results:

  • Achieved an F-score of 0.743 for the collective instance-level GN approach.
  • Exploiting full-text section characteristics improved F-scores by up to 1.8% in information-scarce sections.
  • A refinement process enhanced gene mention recognition by 0.125 and GN by 0.03.

Conclusions:

  • The collective instance-level GN approach significantly improves gene name disambiguation in biomedical literature.
  • The IGN corpus and proposed methods provide a valuable resource for advancing gene normalization research.
  • Future work includes expanding the corpus and extending the approach to other species.