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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis III: Management01:26

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Related Experiment Video

Updated: May 5, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

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10-years experience with the Athero-Express study.

Willem E Hellings1, Frans L Moll, Dominique P V de Kleijn

  • 1Department of Radiology, St. Antonius Hospital, Nieuwegein, The Netherlands;

Cardiovascular Diagnosis and Therapy
|November 28, 2013
PubMed
Summary
This summary is machine-generated.

The Athero-Express study investigates atherosclerotic plaque composition to predict cardiovascular events. Understanding plaque characteristics is crucial for identifying high-risk patients and advancing vascular disease research.

Keywords:
Athero-Express studyatherosclerosisbiobanking researchthrombosis

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Related Experiment Videos

Last Updated: May 5, 2026

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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Area of Science:

  • Cardiovascular Research
  • Pathology
  • Biobanking

Background:

  • Atherosclerotic plaque composition varies, with inflammatory lipid-rich plaques often linked to thrombotic events.
  • The long-term development of atherosclerosis complicates human studies on disease natural history.
  • Predictive value of plaque composition for adverse cardiovascular events remains unclear, necessitating further research.

Purpose of the Study:

  • To elucidate markers for atherosclerotic disease progression.
  • To identify patients at high risk for vascular events.
  • To refine treatment allocation and establish surrogate endpoints for pharmaceutical studies.

Main Methods:

  • The Athero-Express study, a large-scale vascular biobank, collects vascular specimens and clinical follow-up data.
  • Prospective analysis of local atherosclerotic plaques in relation to future vascular outcomes.
  • Readout assessment via histology, RNA, and protein levels.

Main Results:

  • Overview of Athero-Express biobank results since 2002.
  • Discussion of clinical implications of plaque composition studies.
  • Exploration of future directions in biobanking research.

Conclusions:

  • The Athero-Express biobank provides a unique resource for prospective studies on atherosclerosis.
  • Understanding plaque characteristics is key to predicting cardiovascular events.
  • Biobanking research holds significant promise for advancing cardiovascular medicine.