Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

166
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
166
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

8.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.5K
Genetic Lingo01:11

Genetic Lingo

84.9K
Overview
84.9K
Color Vision01:24

Color Vision

2.0K
Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Power-based versus conventional transcranial color-coded duplex sonography in the assessment of the vertebrobasilar-posterior system.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2007
Same author

Intravenous immunoglobulin in primary and secondary chronic progressive multiple sclerosis: a randomized placebo controlled multicentre study.

Multiple sclerosis (Houndmills, Basingstoke, England)·2007
Same author

Diffusion tensor imaging-based fractional anisotropy quantification in the corticospinal tract of patients with amyotrophic lateral sclerosis using a probabilistic mixture model.

AJNR. American journal of neuroradiology·2007
Same author

Oral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot study.

European journal of neurology·2006
Same author

Distribution of grip force in three different functional prehension patterns.

Journal of medical engineering & technology·2006
Same author

Predictors of gastric emptying in Parkinson's disease.

Neurogastroenterology and motility·2006

Related Experiment Video

Updated: May 5, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

5.7K

Impaired colour discrimination in Huntington's disease.

T Büttner1, S Schulz, W Kuhn

  • 1Department of Neurology, Ruhr-University Bochum, St.-Josef-Hospital, Bochum, Germany.

European Journal of Neurology
|November 29, 2013
PubMed
Summary
This summary is machine-generated.

Huntington's disease (HD) significantly impairs color discrimination, affecting red-green and blue-yellow axes. However, visual contrast sensitivity remains normal in HD patients, suggesting specific visual pathway involvement.

More Related Videos

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
10:24

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

12.9K
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

11.3K

Related Experiment Videos

Last Updated: May 5, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

5.7K
Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
10:24

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

12.9K
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

11.3K

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Genetics

Background:

  • Huntington's disease (HD) is a neurodegenerative disorder with complex clinical manifestations.
  • Visual system dysfunctions are increasingly recognized as a component of HD.
  • Understanding visual deficits in HD can offer insights into disease mechanisms and potential therapeutic targets.

Purpose of the Study:

  • To investigate color discrimination and visual contrast perception in patients with Huntington's disease.
  • To compare visual performance in HD patients with age- and sex-matched healthy controls.
  • To explore potential neuroanatomical correlates of visual dysfunction in HD.

Main Methods:

  • Utilized the Farnsworth-Munsell 100 Hue test (FM) to assess color discrimination.
  • Employed stationary contrast targets to evaluate spatial contrast sensitivity.
  • Recruited 18 patients with Huntington's disease and 18 healthy volunteers for comparison.

Main Results:

  • Patients with HD exhibited significantly elevated mean total error scores (MTES) on the FM test compared to controls (HD: 113.0 ± 90.8 vs. Controls: 19.2 ± 8.8).
  • Color discrimination deficits were observed along both the "red-green" and "blue-yellow" axes in HD patients.
  • Spatial contrast sensitivity was found to be normal in the HD patient group.

Conclusions:

  • The findings demonstrate a significant color perception dysfunction in Huntington's disease, indicating visual system involvement.
  • This visual disorder may stem from neurotransmitter imbalances within the visual system of HD patients.
  • Potential sites for this color discrimination abnormality include the retinal cone system and/or impaired parvocellular central visual pathways in HD.