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Antibody radiolabeling techniques to optimize cellular retention

Stephen J Archibald1

  • 1Positron Emission Tomography Research Centre and Department of Chemistry, The University of Hull , Cottingham Road, Hull, HU6 7RX, U.K.

Journal of Medicinal Chemistry
|November 29, 2013
PubMed

Radiolabeling of antibodies and antibody fragments facilitates the development of new targeted therapeutics or tracking and validation of biosimilars. The typical metal ion chelators that can be used for radiolabeling reactions have residualizing properties in tissues/tumors. A team at Genentech has developed an elegant new technique for combining iodine radiolabeling with an azamacrocyclic chelator to confer residualizing properties on the radioiodine metabolites. Robust protocols, such as this example, are required for the future development of protein based drugs.

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