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Updated: May 5, 2026

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
Published on: March 7, 2025
Interview: from Down's syndrome to basic epigenetics and back again.
Jeanne Lawrence1, Caroline Telfer
1Department of Cell & Developmental Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. jeanne.lawrence@umassmed.edu.
Dr. Jeanne Lawrence
Area of Science:
- Epigenetics and Genome Regulation
- Noncoding RNA Biology
- Chromosome Organization
Background:
- Dr. Lawrence's career focuses on chromosome regulation by noncoding RNA and nuclear organization.
- Her work integrates fundamental genome regulation with epigenetic clinical implications.
- She is recognized for developing sensitive FISH technology for gene and RNA detection.
Discussion:
- Her lab demonstrated cell type-specific gene organization and the role of XIST noncoding RNA in X-chromosome silencing.
- Research revealed a novel architectural role for noncoding RNA in scaffolding nuclear bodies.
- Studies explored repeat sequences in chromosome regulation and cancer deregulation.
Key Insights:
- Epigenetic regulation in stem cells.
- Unanticipated roles of repeat sequences in chromosome regulation and cancer.
- Translating X-chromosome inactivation mechanisms to correct trisomy 21 dosage imbalance.
Outlook:
- Potential for novel therapeutic strategies targeting chromosomal abnormalities.
- Advancing understanding of noncoding RNA functions in genome stability.
- Bridging basic science discoveries with clinical applications in genetic disorders.
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