Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

26.7K
Overview
26.7K
Epigenetic Regulation01:37

Epigenetic Regulation

3.5K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.5K
Epigenetic Regulation01:46

Epigenetic Regulation

28.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.8K
Epigenetic Regulation01:46

Epigenetic Regulation

24.1K
24.1K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

293
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
293
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

129
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
129

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DNA Methylation at Birth Showing Age-Specific Association with Atopy in Children: A Prospective Longitudinal Study.

Epigenomes·2026
Same author

Trajectories of Body Mass Index in the First 18 Years of Life and Eczema in Early Adulthood: A Prospective Cohort Study.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Highlights from the 2025 Symposium of the Collegium Internationale Allergologicum.

The Journal of allergy and clinical immunology·2026
Same author

Joint modelling of wheeze and lung function from childhood to early adulthood: four population-based birth cohorts.

EClinicalMedicine·2026
Same author

Epigenome-Wide DNA Methylation Levels During Pregnancy: Associations with Parity Across Diverse Populations.

Epigenomes·2026
Same author

Predicting Lung Function from Voice Recordings Using Machine Learning: An Optimised Approach.

Studies in health technology and informatics·2026

Related Experiment Video

Updated: May 5, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

9.2K

Epigenomics and allergic disease.

Gabrielle A Lockett1, Veeresh K Patil, Nelís Soto-Ramírez

  • 1Human Development & Health, Faculty of Medicine, University of Southampton, Southampton, UK.

Epigenomics
|November 29, 2013
PubMed
Summary
This summary is machine-generated.

Environmental factors influence allergic disease through epigenetic mechanisms like DNA methylation. Understanding this link is key for future diagnosis and treatment of allergies.

More Related Videos

Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

630
Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.7K

Related Experiment Videos

Last Updated: May 5, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

9.2K
Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

630
Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.7K

Area of Science:

  • Environmental epigenetics
  • Immunology
  • Allergy research

Background:

  • Allergic disease development involves genetic and environmental factors.
  • Epigenetic mechanisms, particularly DNA methylation, are hypothesized to mediate environmental influences on allergies.

Purpose of the Study:

  • To discuss the relationship between environment, DNA methylation, and allergic disease.
  • To address causality issues in DNA methylation analyses.
  • To review practical aspects of epigenetic research in allergies.

Main Methods:

  • Description of allergic phenotypes.
  • Comparison of epidemiologic study designs for epigenetic research.
  • Examination of methodological considerations for DNA methylation data analysis.

Main Results:

  • DNA methylation is intricately linked with allergic disease.
  • Current methods and technologies in DNA methylation analysis are rapidly advancing.

Conclusions:

  • The connection between DNA methylation and allergic disease offers potential for future diagnostic and therapeutic strategies.
  • Further research into epigenetic marks is crucial for understanding and managing allergic conditions.