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Evaluation of nestin in lung adenocarcinoma: relation to VEGF and Bcl-2
Manal Basyouni Ahmed1, Enas Samir Nabih, Manal Louis Louka
1Department of Medical Biochemistry and.
Context:
Nestin is a marker of multipotent precursor cells that is up regulated in cancer.
Objective:
To explore its diagnostic role and its relationship to vascular endothelial growth factor (VEGF) and Bcl-2 in lung adenocarcinoma.
Materials And Methods:
Evaluation of nestin expression in lung biopsies by real-time PCR and serum VEGF and Bcl-2 by ELISA in 27 adenocarcinoma patients and 15 control subjects.
Results:
Nestin was significantly higher in lung adenocarcinoma patients especially with advanced grade and stage and it was significantly correlated to VEGF and Bcl-2.
Conclusion:
Nestin can be considered as a potential diagnostic marker in lung adenocarcinoma.
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