[Analysis of relationship between patients with chromosomal translocation and the outcome of pregnancy]

To explore the relationship between chromosome translocation and their phenotypic effect by analyzing the patients with loss pregnancy and avoiding fetuses with chromosomal abnormalities.

A total of 3067 cases with infertility or loss pregnancy were recruited to receive chromosome examination during January 2005 to December 2011 at Center of Prenatal Diagnosis, Peking University People's Hospital. Retrospective study was used to analyze the chromosome karyotypes and infertility or loss pregnancy.

In 72 cases of patients with chromosome translocation, there were 17 pregnancies with homology translocation in fetus. And the numbers of patients with loss pregnancy and sex apparatus malformations were 40 and 15 respectively.

Chromosome translocation plays an important role in patients with loss pregnancy or infertility. And chromosome examination should be performed to exclude the possibility of chromosome abnormities in patients with obstinate infertility.