Related Experiment Video

Updated: May 5, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

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Cardiac sarcoidosis and coronary artery disease: a two-hit mechanism to left ventricular dysfunction (or is it)?

J C Hansen1, A R Patel, H N Nayak

  • 1Section of Cardiology, University of Chicago, Chicago, Illinois. jbeshai@medicine.bsd.uchicago.edu.

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG
|November 29, 2013
PubMed

Insights

This case report details cardiac sarcoidosis in a man with few coronary artery disease risk factors. It emphasizes ruling out ischemia in patients with reduced left ventricular function.

Area of Science:

  • Cardiology
  • Immunology
  • Pathology

Background:

  • Cardiac sarcoidosis is a rare granulomatous disease affecting the heart.
  • It can mimic ischemic heart disease, leading to diagnostic challenges.

Observation:

  • A 40-year-old man with minimal coronary artery disease risk factors presented with declining left ventricular function.
  • Coronary angiography revealed a critical coronary lesion.

Findings:

  • The patient was diagnosed with cardiac sarcoidosis.
  • This diagnosis was made despite a lack of typical risk factors for premature coronary artery disease.

Implications:

  • The case highlights the importance of considering cardiac sarcoidosis in patients with unexplained left ventricular dysfunction.
  • It raises questions about a potential association between sarcoidosis and early-onset coronary artery disease.
  • Diagnostic and therapeutic strategies for cardiac sarcoidosis require careful consideration.

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