Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

849
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
849
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

955
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
955
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

647
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
647
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

1.8K
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.8K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.4K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.4K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

582
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
582

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An exploration of markers of microvascular dysfunction in kidney transplant recipients randomized to belatacept: no clinical impact of CNIs on endothelial function.

Frontiers in transplantation·2026
Same author

Chronic kidney disease in Norwegian primary care: underdiagnosis and undertreatment - findings from the VISTAKID (Vestfold Investigation of Stage 3-5 Kidney Disease) study.

BMC nephrology·2026
Same author

Epidemiology and clinical presentation of kidney amyloidosis have changed over the past three decades: a nationwide population-based study.

BMC nephrology·2025
Same author

Systemic inflammation is an important risk factor and predictor of graft loss and mortality one year after kidney transplantation.

Frontiers in immunology·2025
Same author

Hip geometry and strength remain stable the first year after kidney transplantation-an ibandronate/placebo <i>post hoc</i> analysis.

JBMR plus·2024
Same author

Cellular immunity against cytomegalovirus and risk of infection after kidney transplantation.

Frontiers in immunology·2024
Same journal

KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

Kidney international·2026
Same journal

Crystal-storing histiocytosis causing severe acute kidney injury.

Kidney international·2026
Same journal

Peritoneal dialysis in a patient with extensive burn scarring.

Kidney international·2026
Same journal

COPA syndrome unmasked by anti-neutrophil cytoplasmic antibody-positive immune-complex nephritis.

Kidney international·2026
Same journal

Monitoring anti-nephrin antibodies in the management of recurrent diffuse podocytopathy.

Kidney international·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

15.8K

Long-term risks for kidney donors.

Geir Mjøen1, Stein Hallan2, Anders Hartmann1

  • 1Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway.

Kidney International
|November 29, 2013
PubMed
Summary
This summary is machine-generated.

Living kidney donors face increased long-term risks of all-cause mortality, cardiovascular death, and end-stage renal disease (ESRD). This study compared donors to eligible non-donors, revealing higher mortality and ESRD rates in the donor group.

More Related Videos

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

20.4K
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.4K

Related Experiment Videos

Last Updated: May 5, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

15.8K
Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

20.4K
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.4K

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Public Health

Background:

  • Previous research suggested living kidney donors had good long-term outcomes.
  • However, prior studies often used less healthy control groups and had shorter follow-up periods.

Purpose of the Study:

  • To compare long-term renal function and mortality in living kidney donors versus a carefully selected control group of eligible non-donors.

Main Methods:

  • A cohort of 1901 living kidney donors (1963-2007) was compared to 32,621 eligible non-donors.
  • Median follow-up was 15.1 years for donors and 24.9 years for controls.
  • Outcomes analyzed included all-cause mortality, cardiovascular mortality, and end-stage renal disease (ESRD).

Main Results:

  • Kidney donors had a significantly increased hazard ratio for all-cause death (1.30) and cardiovascular death (1.40).
  • The risk of ESRD was dramatically increased in donors (hazard ratio 11.38), with an incidence of 302 cases per million.
  • Immunological renal disease was the primary cause of ESRD in donors.

Conclusions:

  • Living kidney donors face elevated long-term risks for ESRD, cardiovascular mortality, and all-cause mortality compared to eligible non-donors.
  • These findings highlight the need for ongoing monitoring and risk assessment in kidney donors.
  • Hereditary factors may influence the increased incidence of ESRD in donors.