Related Experiment Video
Updated: May 5, 2026
Re-Arterialized Rat Partial Liver Transplantation with an in vivo Vessel-Oriented 70% Hepatectomy
Published on: April 8, 2018
Segmental grafts in adult and pediatric liver transplantation: improving outcomes by minimizing vascular
Manuel I Rodriguez-Davalos1, Antonios Arvelakis1, Veysel Umman1
1Section of Transplantation and Immunology, Department of Surgery, Yale University School of Medicine, Yale-New Haven Transplantation Center, New Haven, Connecticut.
Importance:
The use of technically variant segmental grafts are key in offering transplantation to increase organ availability.
Objective:
To describe the use of segmental allograft in the current era of donor scarcity, minimizing vascular complications using innovative surgical techniques.
Design, Setting, And Participants:
Retrospective study from August 2007 to August 2012 at a university hospital. A total of 218 consecutive liver transplant patients were reviewed, and 69 patients (31.6%; 38 males and 31 females; mean age, 22.5 years) received segmental grafts from living donors or split/reduced-size grafts from deceased donors.
Main Outcomes And Measures:
Graft type, vascular and biliary complications, and patient and graft survival.
Results:
Of 69 segmental transplants, 47 were living donor liver transplants: 13 grafts (27.7%) were right lobes, 22 (46.8%) were left lobes, and 12 (25.5%) were left lateral segments. Twenty-two patients received deceased donor segmental grafts; of these, 11 (50.0%) were extended right lobes, 9 (40.9%) were left lateral segments, 1 (4.5%) was a right lobe, and 1 (4.5%) was a left lobe. Arterial anastomoses were done using 8-0 monofilament sutures in an interrupted fashion for living donor graft recipients and for pediatric patients. Most patients received a prophylactic dose of low-molecular-weight heparin for a week and aspirin indefinitely. There was no incidence of hepatic artery or portal vein thrombosis. Two patients developed hepatic artery stenosis and were treated with balloon angioplasty by radiology. Graft and patient survivals were 96% and 98%, respectively.
Conclusions And Relevance:
Use of segmental allografts is essential to offer timely transplantation and decrease waiting list mortality. Living donor liver transplants and segmental grafts from deceased donors are complementary. It is possible to have excellent outcomes combining a multidisciplinary team approach, technical expertise, routine use of anticoagulation, and strict patient and donor selection.
