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Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aneurysm I: Introduction01:30

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Thoracic Aorta01:15

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The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
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Sex-linked Disorders01:43

Sex-linked Disorders

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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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Overview
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Aortic Regurgitation I: Introduction01:15

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Related Experiment Video

Updated: May 5, 2026

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
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Heritable thoracic aortic disorders.

Reed E Pyeritz

    Current Opinion in Cardiology
    |November 29, 2013
    PubMed
    Summary

    Genetic mutations cause thoracic aortic disease, affecting the aorta or other organs. Emerging gene-based classifications and novel therapies like angiotensin receptor blockade offer new treatment avenues.

    Area of Science:

    • Genetics
    • Cardiovascular Medicine
    • Molecular Biology

    Background:

    • Thoracic aortic disease stems from diverse causes including inflammation, infection, atherosclerosis, and genetic predispositions.
    • Genetic mutations can lead to syndromic (affecting multiple organs) or nonsyndromic (aorta-limited) aortic conditions.

    Purpose of the Study:

    • To review thoracic aortic diseases caused by specific gene mutations.
    • To explore emerging classifications and novel therapeutic strategies for genetic aortic diseases.

    Main Methods:

    • Literature review focusing on genetic mutations and their impact on thoracic aorta.
    • Analysis of emerging gene-based classification systems for aortic diseases.
    • Evaluation of current and novel therapeutic interventions.

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    Last Updated: May 5, 2026

    Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
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    Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
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    Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
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    Main Results:

    • A classification scheme is emerging based on affected pathways: extracellular matrix (FBN1, COL3A1), TGF-β signaling (TGFBR1, TGFB2), and vascular smooth muscle cell contractility (ACTA2, MYH11).

    Conclusions:

    • Understanding disease pathogenesis is crucial for developing novel therapies, including clinical trials for angiotensin receptor blockade.
    • Established management strategies like imaging, exercise restriction, beta-blockade, and prophylactic surgery remain vital for preventing dissection and sudden death.