Related Experiment Video
Updated: May 5, 2026
07:25
Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
Published on: December 9, 2022
1.9K
Plasma long-chain free fatty acids predict mammalian longevity
Mariona Jové1, Alba Naudí, Juan Carlos Aledo
1Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (IRBLleida), E-25198 Lleida, Spain.
Scientific Reports
|November 29, 2013
Summary
Animal longevity is linked to plasma lipid composition. Lower levels of long-chain free fatty acids (LC-FFA), reduced peroxidizability, and less lipid peroxidation are associated with longer lifespans in mammals.
Area of Science:
- Comparative biology
- Lipidomics
- Gerontology
Background:
- Membrane lipid composition influences animal aging rates and longevity.
- Understanding species-specific lipid profiles can provide insights into lifespan determination.
Purpose of the Study:
- To investigate the relationship between plasma lipidomic profiles and mammalian longevity.
- To identify specific lipid biomarkers associated with lifespan across different species.
Main Methods:
- Utilized high-throughput technologies for non-targeted plasma lipidomic profiling.
- Analyzed 11 mammalian species with maximum longevities ranging from 3.5 to 120 years.
- Performed regression analysis correlating lipid species with longevity, controlling for body mass and phylogeny.
Main Results:
- Discovered species-specific lipidomic profiles that accurately predict animal longevity.
- Found an inverse association between longevity and plasma long-chain free fatty acid (LC-FFA) concentrations.
- Observed lower peroxidizability index and lipid peroxidation products in longer-lived species.
Conclusions:
- Plasma lipidomic signature is a significant feature associated with mammalian longevity.
- Long-chain free fatty acids (LC-FFA) show potential as a biomarker for predicting longevity.
- Lipid metabolism plays a crucial role in determining the lifespan of a species.
More Related Videos
Related Concept Videos
01:31Lipid-derived Compounds in the Human Body
5.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.5K
01:23Membrane Fluidity
150.3K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
150.3K