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Related Experiment Video

Updated: May 5, 2026

Assessment and Characterization of Hyaloid Vessels in Mice

Assessment and Characterization of Hyaloid Vessels in Mice

Published on: May 15, 2019

Collapsing glomerulopathy in collagen vascular-like disease.

R Nasr¹, C Johns, E Gertner

¹1Division of Rheumatology, University of Minnesota Medical School, USA.

|November 29, 2013

Summary

Collapsing glomerulopathy (CG) can present with collagen vascular-like disease, marked by severe proteinuria and renal insufficiency. Rheumatologists should consider this podocytopathy in patients with serological abnormalities but few clinical symptoms.

Keywords:

Collapsing glomerulopathy antinuclear antibody collagen vascular disease podocytopathy

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Area of Science:

Nephrology
Rheumatology
Immunology

Background:

Collapsing glomerulopathy (CG) is a severe podocytopathy often linked to viral infections or defined collagen vascular diseases like lupus.
A subset of patients presents with serological abnormalities suggestive of autoimmune disease but lacks definitive clinical criteria.

Observation:

This study details four new cases of CG with collagen vascular-like disease and reviews 14 similar cases from the literature.
Patients typically present with severe nephrotic-range proteinuria and kidney failure resistant to standard treatments.

Findings:

These patients exhibit positive antinuclear antibodies (ANA) and other significant serological markers without clear clinical rheumatologic diagnoses.
Most affected individuals progress to requiring dialysis.
Mycophenolate mofetil (MMF) shows potential as a therapeutic option.

Implications:

Rheumatologists should be aware of CG as a potential diagnosis in patients with unexplained proteinuria and renal insufficiency.
Early recognition and appropriate consultation are crucial for managing this challenging podocytopathy.