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An efficient laboratory-scale preparative method for [1-(13)C]glycocholic acid
Hidemichi Mitome1, Naoko Tokumasu, Yusuke Tando
1College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime, 790-8578, Japan.
Journal of Labelled Compounds & Radiopharmaceuticals
|November 29, 2013
Summary
A novel breath test using [1-(13)C]glycocholic acid shows promise for diagnosing small intestinal bacterial overgrowth syndrome. This method enables efficient synthesis of the key compound for clinical studies.
Area of Science:
- Biochemistry
- Medical Diagnostics
Background:
- Small intestinal bacterial overgrowth syndrome (SIBO) diagnosis can be challenging.
- Breath tests are a non-invasive diagnostic tool for gastrointestinal disorders.
Purpose of the Study:
- To develop a reliable synthesis method for [1-(13)C]glycocholic acid.
- To support the clinical validation of a [1-(13)C]glycocholic acid breath test for SIBO.
Main Methods:
- Synthesis of [1-(13)C]glycocholic acid from ethyl [1-(13)C]glycinate hydrochloride.
- A one-pot reaction strategy was employed for efficient synthesis.
Main Results:
- [1-(13)C]Glycocholic acid was synthesized in excellent yield.
- The synthesis method is suitable for laboratory-scale preparation.
Conclusions:
- The developed synthesis method facilitates the production of [1-(13)C]glycocholic acid.
- This supports further clinical investigation of the breath test for SIBO diagnosis.
