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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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NONCODEv4: exploring the world of long non-coding RNA genes.

Chaoyong Xie1, Jiao Yuan, Hui Li

  • 1Bioinformatics Research Group, Advanced Computing Research Laboratory, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China, University of Chinese Academy of Sciences, Beijing 100049, China, Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China and Taicang Institute of Life Sciences Information, Suzhou 215400, China.

Nucleic Acids Research
|November 29, 2013
PubMed
Summary
This summary is machine-generated.

The NONCODE database now includes over 210,000 long non-coding RNAs (lncRNAs), significantly expanding its collection. This update enhances understanding of lncRNA genes, their functions, and expression profiles, aiding disease research.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Non-coding RNAs (ncRNAs) play crucial roles in biological processes and disease.
  • High-throughput RNA sequencing (RNA-Seq) has accelerated the discovery of novel ncRNAs.
  • Previous versions of the NONCODE database have been instrumental in cataloging ncRNAs.

Purpose of the Study:

  • To update and expand the NONCODE database with newly identified ncRNAs.
  • To incorporate the latest genomic data from RefSeq and Ensembl.
  • To provide enhanced tools and information for understanding long non-coding RNAs (lncRNAs).

Main Methods:

  • Collection of newly identified ncRNAs from recent literature.
  • Integration of updated RefSeq and Ensembl databases.
  • Generation of lncRNA genes based on alternative splicing patterns.

Main Results:

  • The NONCODE database now contains 210,831 long non-coding RNAs (lncRNAs), a substantial increase from the previous version.
  • 56,018 human and 46,475 mouse lncRNA genes were generated.
  • Expression profiles and predicted functions for lncRNA genes are now available.

Conclusions:

  • The updated NONCODE database provides a comprehensive resource for non-coding RNA research.
  • The introduction of lncRNA genes facilitates a more systematic understanding of these molecules.
  • Enhanced tools and data support further investigation into ncRNA roles in biology and disease.