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Synthesis of [15, 16- ³H] beta-funaltrexamine
Crist N Filer1, Richard J Seguin
1PerkinElmer Life Sciences & Technology Inc., 940 Winter Street, Waltham, MA, 02451, USA.
Journal of Labelled Compounds & Radiopharmaceuticals
|November 29, 2013
Abstract:
Beta-funaltrexamine is a unique irreversible antagonist for the mu-opiate receptor and would be useful as a tritiated radioligand. Starting from high specific activity [15, 16-³H] naltrexone, [15, 16-³H] beta-funaltrexamine was synthesized and characterized by means of a two-step reductive amination-acylation process.
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