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Serious periventricular white matter injury has a significant effect on the voiding pattern of preterm infants

Ya Lun Wang1, Jian Guo Wen, Lu Xing

  • 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China.

Acta Paediatrica (Oslo, Norway : 1992)
|November 30, 2013
PubMed

Insights

Serious periventricular white matter injury (PWMI) significantly alters voiding patterns in preterm infants, leading to reduced frequency and awake voiding. These findings suggest the involvement of the central nervous system in regulating bladder function in premature neonates.

Area of Science:

  • Neonatal Neurology
  • Pediatric Urology
  • Developmental Neuroscience

Background:

  • Periventricular white matter injury (PWMI) is a common complication in preterm infants.
  • Understanding the impact of PWMI on physiological functions is crucial for neonatal care.

Purpose of the Study:

  • To investigate the association between serious PWMI and voiding patterns in preterm infants.
  • To determine if neurological injury affects bladder control in this vulnerable population.

Main Methods:

  • Observational study comparing 19 preterm infants with serious PWMI and 16 healthy controls.
  • Continuous eight-hour observation of free voiding.
  • Recorded parameters included voiding frequency, volume, postvoid residual, and voiding efficiency (empty, awake, interrupted).

Main Results:

  • Preterm infants with serious PWMI exhibited significantly lower voiding frequency, awake voiding percentage, and empty voiding percentage.
  • Conversely, injured infants showed significantly higher voided volumes and postvoid residual volumes compared to controls.
  • These differences were statistically significant (p < 0.05).

Conclusions:

  • Serious PWMI demonstrably impacts the voiding patterns of preterm infants.
  • The findings highlight the role of the central nervous system, specifically the senior nerve centers, in the voiding reflex of preterm neonates.
Abstract

Keywords:
Periventricular white matter injuryPreterm infantsSenior nerve centreVoiding

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