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Updated: May 5, 2026
Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome
Published on: October 26, 2018
Effect of partial liquid ventilation on lung function in oleic acid-induced lung injury model of piglets
Ji-zhuo Zhang1, Ling-ke Li, Yan-bo Zhang
1Department of Cardiovascular Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Insights
Partial liquid ventilation (PLV) did not improve lung function in piglets with acute lung injury. While PLV maintained higher pH and PaO2 levels, it did not significantly alter other key respiratory parameters compared to conventional mechanical ventilation.
Area of Science:
- Pediatric Pulmonology
- Critical Care Medicine
- Respiratory Physiology
Background:
- Pediatric patients are vulnerable to lung injuries unresponsive to standard treatments.
- Partial liquid ventilation (PLV) is an alternative strategy for severe lung injury.
- Investigating PLV's efficacy in immature lung models is crucial.
Purpose of the Study:
- To evaluate the impact of partial liquid ventilation (PLV) on lung function in immature piglets.
- To compare PLV with conventional mechanical ventilation (MV) in a pediatric acute lung injury model.
Main Methods:
- Acute lung injury was induced in 12 piglets using oleic acid.
- Animals were randomized to either conventional mechanical ventilation (MV) or PLV with FC-77 (10 ml/kg).
- Hemodynamic and respiratory parameters, including blood gases, were monitored.
Main Results:
- PLV maintained a higher pH and PaO2 compared to MV (P < 0.05).
- PaCO2 increased in both groups, with significant differences between PLV and MV (P < 0.05).
- No significant improvements were observed in dynamic lung compliance (Cydn) or mean airway pressure (Paw).
Conclusions:
- Partial liquid ventilation (PLV) did not demonstrate improved lung function outcomes in this model.
- Further research is needed to explore potential benefits or modifications of PLV in pediatric lung injury.
Background:
Pediatric patients are susceptible to lung injury that does not respond to traditional therapies. Partial liquid ventilation (PLV) has been developed as an alternative ventilatory strategy for treating severe lung injury. The aim of this study is to investigate the effect of PLV on lung function in immature piglets.
Methods:
Acute lung injury was induced in 12 Chinese immature piglets by oleic acid (OA). The animals were randomly assigned to two groups (n = 6 each group): (1) conventional mechanical ventilation (MV) group and (2) PLV with FC-77 (10 ml/kg) group. Mean arterial blood pressure (MAP), mean pulmonary arterial pressure (MPAP), central venous pressure (CVP), left atrial pressure (LAP), systemic vascular resistance (SVR), pulmonary vascular resistance (PVR), cardiac output (CO), mean pressure of airway (Paw), dynamic lung compliance (Cydn), and arterial blood gases were measured during the observation period.
Results:
No piglet died in either group with severe lung injury. After four hours of ventilation, pH in the MV group gradually decreased to lower than 7.20, while in the PLV group, pH also gradually decreased but remained higher than 7.20 (P < 0.05). Partial pressure of oxygen in artery (PaO2) decreased in both groups, but with a significant difference between the PLV group and MV group (P < 0.05). Partial pressure of carbon dioxide in artery (PaCO2) increased in both groups, but with a significant difference between the PLV group and MV group (P < 0.05). Paw increased in both groups, but was not significantly different (P > 0.05). Cydn decreased in both groups, but without a significant difference (P > 0.05). At four hours, heart rate (HR) and MAP in both groups decreased. MPAP in both groups increased, and there was a significant difference between the two groups (P < 0.05). CVP was stable in both groups. At four hours, PVR and LAP were increased in both groups. CO was decreased in both groups (P < 0.05). SVR was stable during the observation time.
Conclusion:
PLV did not improve outcome in changes of lung function.
