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Multiple Sclerosis l: Introduction01:19

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Systemic sclerosis, birth order and parity.

Paul A J Russo1, Susan Lester, Peter J Roberts-Thomson

  • 1SA Pathology, Immunology Directorate, Flinders Medical Centre, Adelaide, SA, Australia; Department of Immunology, Royal Adelaide Hospital, Adelaide, SA, Australia.

International Journal of Rheumatic Diseases
|November 30, 2013
PubMed
Summary
This summary is machine-generated.

This study found no link between birth order, parity, or family size and systemic sclerosis (SSc) risk. These findings challenge the microchimerism theory in SSc pathogenesis.

Keywords:
birth ordermicrochimerismparitysystemic sclerosis

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Area of Science:

  • Rheumatology
  • Immunology
  • Epidemiology

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease.
  • Previous research suggested a link between increasing birth order and SSc risk.
  • This proposed a role for transplacental microchimerism in SSc development.

Purpose of the Study:

  • To investigate the association between birth order, parity, and SSc onset age.
  • To evaluate the microchimerism hypothesis in SSc pathogenesis.

Main Methods:

  • Retrospective analysis of the South Australian Scleroderma Register.
  • Comparison of 387 SSc patients with 457 controls.
  • Mixed effects logistic regression analysis of birth order, parity, and family size.

Main Results:

  • No statistically significant relationship found between SSc and birth order.
  • Parity, family size, and age at first pregnancy were not significant risk factors.
  • Gender of the first child also showed no association with SSc.

Conclusions:

  • The study data do not support parity, birth order, or family size as relevant factors in SSc epidemiology.
  • Findings argue against microchimerism as a key factor in SSc pathogenesis.
  • Results suggest stochastic events may play a more significant role in SSc development.