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Clinical experience with alpha-adrenoceptor antagonists in benign prostatic hypertrophy
Federation Proceedings
|October 1, 1986
Summary
Alpha-adrenoceptor antagonists effectively treat benign prostatic hyperplasia symptoms by relaxing prostate smooth muscle. Clinical reviews confirm benefits for irritative symptoms and objective urinary flow parameters.
Area of Science:
- Pharmacology
- Urology
Background:
- Benign prostatic hyperplasia (BPH) involves dynamic prostatic obstruction.
- Sympathetic nervous system controls smooth muscle tone in the prostate, influencing obstruction.
Purpose of the Study:
- To review the efficacy of alpha-adrenoceptor antagonists in treating symptomatic BPH.
- To assess their impact on irritative symptoms and objective urodynamic parameters.
Main Methods:
- Review of published clinical experience with alpha-adrenoceptor antagonists.
- Analysis of effects on symptoms like frequency and objective measures such as uroflow and residual urine.
Main Results:
- Alpha-adrenoceptor antagonists significantly improve irritative BPH symptoms (diurnal/nocturnal frequency).
- Demonstrated benefits in objective parameters: uroflow, residual urine, urethral closure pressure, and detrusor instability.
- Effective in prophylaxis or treatment of acute urinary retention in BPH patients.
Conclusions:
- Alpha-adrenoceptor antagonists are valuable for symptomatic BPH treatment.
- Phenoxybenzamine shows significant efficacy, with ongoing assessment of other agents, including combined alpha 1 and alpha 2 antagonists.