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Updated: May 5, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
[Neonatal morbidity in early-term newborns]
S Martínez-Nadal1, X Demestre1, F Raspall1
1SCIAS, Hospital de Barcelona, Barcelona, España.
Insights
Early term births (37-38 weeks) are increasing and show higher rates of neonatal unit admission and respiratory issues compared to full term births. Avoid early term delivery unless medically necessary to reduce infant morbidity.
Area of Science:
- Obstetrics and Gynecology
- Neonatology
- Perinatal Medicine
Context:
- The incidence of early term births (37-38 weeks gestation) has risen significantly over the past two decades.
- This increase coincides with a rise in induced labor and cesarean delivery rates.
- Early term newborns (RNTP) and full term newborns (RNTC) represent distinct populations with potentially different health outcomes.
Purpose:
- To compare the neonatal outcomes of early term newborns (37-38 weeks) with those of full term newborns (39-41 weeks).
- To analyze trends in cesarean section rates and their correlation with gestational age at birth.
- To identify specific morbidities associated with early term birth.
Summary:
- A retrospective cohort study analyzed 35,539 newborns from 1992-2011, comparing early term (n=11,318) and full term (n=24,221) infants.
- Early term infants exhibited significantly higher rates of neonatal unit admission, respiratory morbidity, phototherapy for hyperbilirubinemia, hypoglycemia, and need for parenteral nutrition.
- Cesarean section rates increased overall and were higher for early term births, though no significant differences were found in early sepsis or hypoxic-ischemic encephalopathy rates.
Impact:
- The findings highlight increased neonatal morbidity in early term infants, suggesting a need for careful consideration of delivery timing.
- Results support delaying non-medically indicated deliveries before 39 weeks gestation to improve infant outcomes.
- This research contributes to evidence-based guidelines for optimizing perinatal care and reducing preventable infant complications.
Introduction:
In the last decades has increased significantly The birth of children from 37 to 38 weeks of gestation, a period called early term, has significantly increased in the past twenty years or so, parallel to the increase in induced deliveries and the cesarean rate.
Patients And Method:
Retrospective cohorts population study, which included those babies born between 37 and 41 weeks of gestation in the period 1992-2011 (n=35.539). This population was divided into two cohorts, early term newborn (RNTP) of 37-38 weeks (n=11,318), and full term newborn (RNTC), of 39-41 weeks of gestation (n=24,221). The rates of cesarean section, neonatal unit admission, respiratory morbidity, apnea and need for assisted ventilation, hyperbilirubinemia requiring phototherapy, hypoglycemia, seizures, hypoxic-ischemia encephalopathy, need for parenteral nutrition and early sepsis were all reviewed.
Results:
There was a progressive increase in the number of caesarean sections throughout the period studied (from 30.9% to 40.3%). The cesarean section rate was higher in RNTP than in the RNTC (38.3% vs 31.3%, P<.0001). On comparing the two groups, significant differences were found in the rate of admission to neonatal unit, 9.1% vs 3.5% (P<.0001); respiratory morbidity (hyaline membrane 0.14% vs 0.007% [P<.0001], transient tachypnea 1.71% vs 0.45% [P<.0001], mechanical ventilation 0.2% vs 0.07% [P<.009], continuous positive airway pressure 0.11% vs 0.01% [P<.0001]), phototherapy 0.29% vs 0.07% (P<.0001), hypoglycemia 0.54% vs 0.11% (P<.0001), parenteral nutrition 0.16% vs 0.04% (P<.0001). There were no significant differences in the rate of early sepsis, pneumothorax, aspiration syndromes, seizures and hypoxic-ischemic encephalopathy.
Conclusions:
In our environment, there is a significant number of RNTP, which have a significantly higher morbidity than newborns RNTC registered. After individualizing each case, it is essential not end a pregnancy before 39 weeks of gestation, except for maternal, placental or fetal conditions indicating that continuing the pregnancy may increase the risk for the fetus and/or the mother.
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