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[Relationship between previous severity of illness and outcome of in-hospital cardiac arrest]

M Serrano1, J Rodríguez1, A Espejo1

  • 1Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Instituto de Investigación, Hospital General Universitario Gregorio Marañón, Madrid, Red de Salud Maternoinfantil y del Desarrollo (Red SAMID), Madrid, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|November 30, 2013
PubMed

Insights

Elevated lactic acid levels before in-hospital cardiac arrest (CA) in children may predict mortality. This finding helps identify children at higher risk following CA.

Area of Science:

  • Pediatric critical care medicine
  • Cardiovascular research
  • Biomarker analysis

Context:

  • In-hospital cardiac arrest (CA) in children is a critical event with significant mortality.
  • Understanding prognostic factors is crucial for improving outcomes in pediatric critical care.
  • Previous research has explored various clinical and biochemical markers for predicting CA outcomes.

Purpose:

  • To investigate the predictive value of pre-arrest illness severity scores (PRIMS, PELOD), lactic acid, creatinine, and inotropic index for mortality in pediatric in-hospital CA.
  • To assess the utility of an adult-derived prognostic index in this pediatric population.

Summary:

  • This study analyzed 44 children experiencing in-hospital CA, examining pre-arrest factors and outcomes.
  • Higher pre-arrest lactic acid levels were significantly associated with mortality (P=.04).
  • No significant differences were found in illness severity scores, creatinine, or inotropic index between survivors and non-survivors.

Impact:

  • Identifies elevated lactic acid as a potential prognostic biomarker for pediatric in-hospital CA.
  • Suggests that current adult prognostic indices may not be directly applicable to children.
  • Informs clinical decision-making and risk stratification for critically ill children at risk of CA.
Abstract

Keywords:
Cardiac arrestCardiopulmonary resuscitationCreatininaCreatinineFármacos inotrópicosGravedad clínicaInotropic drugsInotropic indexLactic acidParada cardiacaReanimación cardiopulmonarSeverity of illnessÁcido lácticoÍndice inotrópico

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