Related Experiment Video
Updated: May 5, 2026
05:06
Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
Published on: July 14, 2023
2.6K
Diabetic neuropathy
Aaron I Vinik1, Marie-Laure Nevoret, Carolina Casellini
1Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA.
Endocrinology and Metabolism Clinics of North America
|November 30, 2013
Summary
Diabetic neuropathy is a common diabetes complication causing significant health issues and costs. This review outlines assessment and treatment strategies for diabetic neuropathy and autonomic dysfunction.
Area of Science:
- Neurology
- Endocrinology
- Diabetology
Background:
- Diabetic neuropathy (DN) is a prevalent and serious complication of diabetes mellitus.
- It contributes significantly to morbidity, mortality, and healthcare costs.
- DN often coexists with autonomic neuropathy, necessitating integrated management.
Purpose of the Study:
- To review clinical assessment methods for diabetic peripheral neuropathy.
- To outline treatment options for diabetic neuropathy and associated autonomic dysfunction.
- To provide algorithms for managing painful neuropathy and autonomic complications.
Main Methods:
- Literature review of clinical assessment tools.
- Analysis of current treatment guidelines and algorithms.
- Synthesis of evidence for managing diabetic neuropathy and autonomic dysfunction.
Main Results:
- Diabetic neuropathy requires multifactorial clinical assessment.
- Screening for autonomic neuropathy is crucial due to high comorbidity.
- Established algorithms guide the management of painful neuropathy and autonomic dysfunction.
Conclusions:
- Comprehensive assessment and management are vital for diabetic neuropathy.
- Integrated screening and treatment of peripheral and autonomic neuropathy improve patient outcomes.
- Clinical algorithms provide a structured approach to diabetic neuropathy care.
More Related Videos
11:22Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
Published on: April 29, 2013
12.7K
09:39Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
9.1K
Related Concept Videos
01:22Diabetic Neuropathy
98
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
98
01:31Diabetic Foot Ulcer
41
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
41
01:27Diabetic Retinopathy
65
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
65
01:28Diabetic Nephropathy
49
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
49
01:22Complications of Diabetes Mellitus
43
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
43
01:20Pathophysiology of Diabetes
3.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K