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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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p53 in neurodegenerative diseases and brain cancers

Frédéric Checler1, Cristine Alves da Costa1

  • 1Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/UNS, "Labex Distalz", 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.

Pharmacology & Therapeutics
|November 30, 2013
PubMed

Insights

The tumor suppressor protein p53 plays a key role in both neurodegenerative diseases like Alzheimer's and Parkinson's, and in cancers. Research explores strategies to target p53 dysfunction in these conditions.

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Oncology

Background:

  • The p53 protein, initially identified through its interaction with SV40, is a crucial tumor suppressor.
  • p53 regulates critical cellular processes including growth arrest and apoptosis.
  • Dysregulation of p53 is implicated in diverse pathologies, including neurodegeneration and cancer.

Purpose of the Study:

  • To review the link between p53 and neurodegenerative diseases and brain cancers.
  • To document therapeutic strategies targeting p53 dysfunction in these disorders.

Main Methods:

  • Literature review of studies on p53 in neurodegeneration and cancer.
  • Analysis of data connecting p53 to Alzheimer's and Parkinson's diseases.
  • Documentation of therapeutic approaches for p53-related pathologies.

Main Results:

  • p53 is central to pathologies with either exacerbated or impaired apoptosis.
  • In neurodegenerative diseases (Alzheimer's, Parkinson's), enhanced cell death involves p53.
  • In cancers, p53 mutations impair apoptosis, contributing to disease progression.

Conclusions:

  • p53 is a critical factor in both neurodegenerative conditions and malignancies.
  • Targeting p53 offers potential therapeutic avenues for brain cancers and neurodegenerative disorders.
Keywords:
Alzheimer's diseaseCerebral cancersParkinson's diseaseSignalingTherapeuticsp53

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