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Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
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Updated: Jan 24, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers
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Current research on organ donor management.

Mitchell Sally1, Darren Malinoski

  • 1Portland VA Medical Center, Oregon Health & Science University, PO Box 1034/Mail Code P3ANES, Portland, OR 97207, USA.

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Organ donor management is crucial due to organ shortages. This review highlights research to optimize organ recovery and transplantation, addressing the gap in evidence-based guidelines for potential organ donors.

Keywords:
Donor management goalsGraft outcomesOrgan donationOrgan donor managementTransplantation

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Area of Science:

  • Medicine
  • Transplantation Medicine
  • Critical Care

Background:

  • A significant organ shortage exists, with 116,000 patients awaiting transplants in the US.
  • Demand for organs far exceeds supply, necessitating optimization of donor organs.
  • Limited research exists on optimal donor management therapies, presenting significant challenges.

Purpose of the Study:

  • To review existing literature on organ donor management.
  • To highlight recent clinical trials guiding donor management.
  • To address the lack of evidence-based guidelines in this critical area.

Main Methods:

  • Literature review of existing studies on organ donor management.
  • Analysis of recent clinical trials in the field.
  • Synthesis of findings to guide clinical practice.

Main Results:

  • Research in organ donor management is increasing despite challenges.
  • Existing literature and recent trials offer insights into optimizing donor management.
  • Evidence-based guidelines are currently lacking but are an area of active research.

Conclusions:

  • Optimizing donor management is essential to maximize transplants from limited donors.
  • Further research and evidence-based guidelines are needed to improve organ recovery and transplantation outcomes.
  • This review provides a foundation for understanding current practices and future directions in organ donor management.