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Improved cosmetic activity by optimizing the Lithospermum erythrorhizon extraction process.

Ji Seon Kim1, Yong Chang Seo, Ra Hwan No

  • 1Department of Medical Biomaterials Engineering, Kangwon National University, Chuncheon, Gangwon, 200-701, Republic of Korea.

Cytotechnology
|November 30, 2013
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Summary

This study optimized extraction methods for Lithospermum erythrorhizon, enhancing its potential for skin whitening and immune support cosmetics. Optimized ultrasonic and high-pressure extraction significantly increased shikonin content and improved cosmeceutical properties.

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Area of Science:

  • Cosmeceutical research
  • Natural product chemistry
  • Dermatology

Background:

  • Lithospermum erythrorhizon is a natural dye source with potential cosmetic applications.
  • Optimizing extraction methods is crucial for maximizing the yield and efficacy of its active compounds for cosmeceutical use.

Purpose of the Study:

  • To optimize ultrasonic extraction (UE) and high-pressure extraction (HPE) conditions for Lithospermum erythrorhizon.
  • To evaluate the cosmeceutical properties of the optimized extracts, focusing on skin whitening and immune activation.
  • To provide cosmeceutical data on extraction yield and shikonin content.

Main Methods:

  • Optimized ultrasonic extraction (120 kHz for 90 min) and high-pressure extraction (500 MPa for 60 min).
  • Assessed extraction yield and shikonin content.
  • Evaluated hyaluronidase inhibition, MMP-1 expression, prostaglandin E2 production, tyrosinase inhibition, and melanin production.

Main Results:

  • Optimal conditions yielded 27.49% extraction yield and 3.19% shikonin content, significantly higher than conventional ethanol extract (16.32% and 1.81%).
  • UE + HPE extract showed enhanced hyaluronidase inhibition (64.19% vs. 44.24%), reduced MMP-1 expression, and lower prostaglandin E2 production, indicating immune activation.
  • Skin whitening activity was improved, with UE + HPE extract showing 67.15% tyrosinase inhibition and reducing melanin production to 79.5%, comparable to ascorbic acid.

Conclusions:

  • Optimized UE + HPE significantly improves Lithospermum erythrorhizon extraction yield and shikonin content.
  • The optimized extract demonstrates potent skin whitening and immune-activating properties, making it a valuable ingredient for cosmeceuticals.
  • This study provides valuable cosmeceutical data supporting the expanded use of Lithospermum erythrorhizon in skincare products.