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Relationship between liver function tests and thyroid hormones in thyroid disorders.

M O Ajala1, P S Ogunro, O A Fasanmade

  • 1Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology. Osogbo. Nigeria.

The Nigerian Postgraduate Medical Journal
|November 30, 2013
PubMed
Summary
This summary is machine-generated.

Thyroid dysfunction significantly impacts liver function tests, altering enzyme levels and correlations. Caution is advised when interpreting liver function tests in patients with thyroid disorders.

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Area of Science:

  • Endocrinology
  • Hepatology
  • Clinical Biochemistry

Background:

  • Thyroid hormones play a crucial role in regulating metabolic processes throughout the body.
  • Alterations in thyroid hormone levels can affect various organ systems, including the liver.

Purpose of the Study:

  • To evaluate the impact of hyperthyroidism and hypothyroidism on liver function tests (LFTs).
  • To investigate the correlation between thyroid dysfunction and liver enzyme levels.

Main Methods:

  • Studied 68 subjects with thyroid dysfunction (40 hyperthyroid, 28 hypothyroid) and 40 healthy controls.
  • Measured plasma levels of albumin, bilirubin, thyroid hormones (T4, T3, TSH), and liver enzymes (AST, ALT, ALP, GGT).

Main Results:

  • Significantly increased total bilirubin and liver enzyme activities were observed in both hyperthyroid and hypothyroid subjects.
  • Correlations between thyroid hormones and liver enzymes showed opposite trends in hyperthyroid versus hypothyroid individuals.

Conclusions:

  • Both hyperthyroidism and hypothyroidism demonstrably alter liver function tests.
  • Interpretation of LFTs in patients with thyroid dysfunction requires careful consideration.