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Comparative genetics of warfarin resistance

J Oldenburg1, C R Müller, S Rost

  • 1Prof. Dr. Johannes Oldenburg, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str. 25, 53105 Bonn, Germany, E-mail: johannes.oldenburg@ukb.uni-bonn.de, Tel. +49/(0)228/287 51 75, Fax +49/(0)228/287 51 76.

Hamostaseologie
|November 30, 2013
PubMed
Summary

Warfarin resistance in rodents and humans is caused by mutations in the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) gene. This review details VKORC1 mutations, their genetic mechanisms, and differences between species.

Keywords:
3-epoxide reductase complex subunit 1GeneticsVKORC1vitamin K 2warfarin resistance

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