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Updated: May 5, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
Vacuum phenomenon: Clinical relevance
Ishan Gohil1, Joel A Vilensky, Edward C Weber
1Department of Anatomy and Cell Biology, Indiana University School of Medicine, Fort Wayne, Indiana.
The vacuum phenomenon (VP) is often mistaken for serious joint pathology but is usually benign. Recognizing true VP prevents misdiagnosis and ensures appropriate patient care.
Area of Science:
- Radiology
- Anatomy
- Medical Imaging
Background:
- Vacuum phenomenon (VP) is an anatomical finding that can complicate joint pathology diagnosis.
- VP is observed across various imaging modalities, including radiography, CT, and MRI.
- It is frequently associated with degenerative joint disease but also occurs in other conditions.
Purpose of the Study:
- To review the literature on the vacuum phenomenon.
- To clarify its underlying mechanisms, associated pathologies, and clinical significance.
- To establish diagnostic criteria and a workup algorithm for VP.
Main Methods:
- Literature review to synthesize information on VP.
- Analysis of imaging characteristics (CT, GRE-MRI, multipositional views).
- Development of diagnostic criteria and a clinical algorithm.
Main Results:
- VP formation is explained by gas solubility, pressure-volume relationships, and physiology.
- CT, GRE-MRI, and multipositional views are optimal for visualizing VP.
- VP is often underreported, particularly outside the spine, and can be mistaken for serious pathology.
Conclusions:
- VP is a common, often benign finding that requires accurate identification.
- Distinguishing VP from other joint pathologies is crucial to avoid misdiagnosis and inappropriate treatment.
- VP should be considered in the differential diagnosis of joint pain, especially in elderly patients.
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