Related Experiment Video

Updated: May 5, 2026

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control
05:41

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Published on: December 16, 2022

4.0K

Is being an elderly woman a risk factor for worse outcomes after percutaneous coronary intervention? A large cohort

Zhan Gao1, Jin-Qing Yuan2, Bo Xu1

  • 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Angiology
|November 30, 2013
PubMed

Insights

Elderly females (>75) experienced higher cardiac death rates after percutaneous coronary intervention (PCI). However, being an elderly female was not an independent risk factor for worse PCI outcomes compared to elderly males.

Area of Science:

  • Cardiology
  • Geriatrics
  • Interventional Cardiology

Background:

  • The impact of combined advanced age and female sex on outcomes after percutaneous coronary intervention (PCI) remains unclear.
  • Understanding specific risk factors is crucial for optimizing patient care and improving outcomes in cardiovascular interventions.

Purpose of the Study:

  • To determine if elderly females (>75 years) represent a distinct risk group for adverse outcomes following PCI.
  • To compare the 3-year cardiac death and cardiac death/myocardial infarction (MI) rates between elderly females and other demographic groups undergoing PCI.

Main Methods:

  • Analysis of a large cohort of 29,211 consecutive patients who underwent PCI.
  • Utilized Kaplan-Meier survival estimates to assess 3-year cardiac death rates.
  • Employed Cox proportional hazard models to identify significant risk factors for adverse outcomes.

Main Results:

  • Elderly females showed a significantly higher 3-year rate of cardiac death compared to other groups (P < .05).
  • Being an elderly female was a significant risk factor for cardiac death and cardiac death/MI when compared to young females or young males.
  • However, elderly female status was not a significant independent risk factor for worse PCI outcomes when compared to elderly males.

Conclusions:

  • While elderly females exhibit worse outcomes post-PCI, their demographic status alone is not an independent predictor of adverse events when compared to elderly males.
  • Further research may be needed to elucidate the specific factors contributing to poorer outcomes in this population.
  • Clinical management strategies should consider age and sex but also individual patient factors for periprocedural risk assessment.

Keywords:
elderly womenoutcomespercutaneous coronary intervention

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
400
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
450
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
376
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
500
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
891