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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Diabetic Nephropathy01:28

Diabetic Nephropathy

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Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Chronic Kidney Disease IV: Nursing Management01:18

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Related Experiment Video

Updated: May 5, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multiple myeloma and kidney disease.

Daisuke Katagiri1, Eisei Noiri, Fumihiko Hinoshita

  • 1Department of Nephrology and Endocrinology, University Hospital, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.

Thescientificworldjournal
|November 30, 2013
PubMed
Summary

Multiple myeloma patients with kidney damage benefit from new dialysis and chemotherapy. Early reduction of free light chains (FLC) improves kidney function and reduces dialysis dependence.

Area of Science:

  • Nephrology
  • Hematology
  • Oncology

Background:

  • Multiple myeloma (MM) frequently affects the elderly, exhibiting significant patient heterogeneity impacting treatment response.
  • Chronic kidney disease (CKD) is a common comorbidity in MM, associated with increased mortality and morbidity.
  • Acute kidney injury (AKI) in MM is often caused by monoclonal immunoglobulin free light chains (FLC) inducing tubulointerstitial nephropathy.

Purpose of the Study:

  • To explore novel management strategies for MM patients with CKD.
  • To evaluate the efficacy of combined extended high cutoff hemodialysis and chemotherapy in reducing FLC levels and improving renal outcomes.

Main Methods:

  • Utilizing recent advancements in diagnostic tests, chemotherapy, and dialysis techniques.
  • Implementing extended high cutoff hemodialysis in conjunction with chemotherapy regimens.

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  • Monitoring serum FLC concentrations and assessing kidney function recovery and dialysis independence.

    • Main Results:

    • Early reduction in serum FLC concentration correlates with improved kidney function in AKI settings.
    • The combination therapy achieved sustained FLC reductions in most patients.
    • A high rate of independence from dialysis was observed in the treated patient cohort.

    Conclusions:

    • Novel therapeutic approaches offer improved management for MM patients with CKD.
    • Combined extended high cutoff hemodialysis and chemotherapy effectively reduce FLC levels and enhance renal recovery.
    • These advancements hold promise for improving the quality of life and prognosis for MM patients with kidney impairment.