Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

26
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
26
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

49
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
49
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.2K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.2K
Diagnosing Acidosis and Alkalosis01:24

Diagnosing Acidosis and Alkalosis

1.6K
Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2  and...
1.6K
Diabetic Ketoacidosis l: Introduction01:25

Diabetic Ketoacidosis l: Introduction

41
DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic...
41

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing carbon nanotubes production from pyrolysis-catalysis of plastic waste through monolithic heating.

National science review·2026
Same author

Reinforced biotubes as readily available and regenerative vascular grafts.

Nature communications·2026
Same author

Advances in Surface Biofunctionalization and Intelligent Monitoring of Vascular Scaffolds.

Research (Washington, D.C.)·2026
Same author

Tissue-Inducing Biomaterials for Cardiac Tissue Regeneration and Repair.

Tissue engineering. Part A·2025
Same author

Hyaluronic acid-hydroxyapatite composite hydrogels for tissue filling and soft tissue regeneration.

Journal of colloid and interface science·2025
Same author

Economic growth and sustainable material innovation in the circular economy: Dynamic ARDL evidence on environmental and technological moderators.

Journal of environmental management·2025

Related Experiment Video

Updated: May 5, 2026

Quantification of Coenzyme A in Cells and Tissues
08:51

Quantification of Coenzyme A in Cells and Tissues

Published on: September 27, 2019

8.2K

Clinical spectrum of propionic acidaemia.

Muhammad Rafique1

  • 1Department of Child Health, College of Medicine, King Khalid University, Abha 61321, Saudi Arabia.

Journal of Nutrition and Metabolism
|November 30, 2013
PubMed
Summary

Propionic acidemia (PA) often presents in newborns with diverse symptoms like lethargy and vomiting, alongside metabolic disturbances. Early diagnosis and intervention are crucial for preventing severe complications and improving quality of life.

Area of Science:

  • Biochemistry
  • Genetics
  • Pediatrics

Background:

  • Propionic acidemia (PA) is an inherited metabolic disorder.
  • Early identification of clinical and laboratory features is essential for timely management.
  • Understanding PA's presentation aids in distinguishing it from other neonatal conditions.

Purpose of the Study:

  • To evaluate the clinical features, physical findings, diagnosis, and laboratory parameters in patients with propionic acidemia.
  • To analyze the spectrum of symptoms and metabolic derangements associated with PA.
  • To identify key indicators for early diagnosis and potential intervention strategies.

Main Methods:

  • Retrospective review of medical records for diagnosed cases of propionic acidemia.
  • Analysis of 133 admissions across 26 patients.

More Related Videos

Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems
14:42

Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems

Published on: September 23, 2021

6.7K
Author Spotlight: Exploring Venous Waveforms for Non&#45;Invasive Respiratory Monitoring in Pigs
04:10

Author Spotlight: Exploring Venous Waveforms for Non-Invasive Respiratory Monitoring in Pigs

Published on: March 8, 2024

2.0K

Related Experiment Videos

Last Updated: May 5, 2026

Quantification of Coenzyme A in Cells and Tissues
08:51

Quantification of Coenzyme A in Cells and Tissues

Published on: September 27, 2019

8.2K
Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems
14:42

Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems

Published on: September 23, 2021

6.7K
Author Spotlight: Exploring Venous Waveforms for Non&#45;Invasive Respiratory Monitoring in Pigs
04:10

Author Spotlight: Exploring Venous Waveforms for Non-Invasive Respiratory Monitoring in Pigs

Published on: March 8, 2024

2.0K
  • Evaluation of clinical manifestations, physical findings, and laboratory parameters during admissions.

    • Main Results:

    • 85% of patients showed clinical manifestations within the first week of life.
    • Common clinical features included lethargy, fever, vomiting, hypotonia, and respiratory symptoms (51-92% of admissions).
    • Metabolic crises, acidosis, hyperammonemia, hypoalbuminemia, and hypocalcemia were frequent (30-96% of admissions); brain edema and atrophy were noted in 17% and 25% of admissions, respectively.

    Conclusions:

    • Propionic acidemia typically presents with a broad range of clinical and laboratory abnormalities in the neonatal period.
    • The condition is linked to significant complications impacting patient quality of life.
    • Early diagnosis and prompt intervention are critical for potentially preventing severe outcomes.