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Updated: May 5, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Changes in the retina in induced hypoestrogenia (according to optical coherent tomography data)
A S Obrubov1, S A Obrubov, I B Medvedev
1Department of Ophthalmology, Faculty for Continuous Medical Education; Department of Ophthalmology, Pediatric Faculty; Department of Histology, Therapeutic Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. obrubovs@yandex.ru.
Abstract:
Ultrastructural changes in the retina under conditions of experimental hypoestrogenia were studied. Hypoestrogenic status was induced in female rabbits by extirpation of both uterine horns with appendages. Clinical status of the eyes was evaluated after 9 months by ophthalmoscopy and optical coherent tomography. Changes in the retinal layers under conditions of experimental estrogenia were detected: thickened retinal pigmented epithelium layer, a lesser layer of nerve fibrils, and thinning of the choriocapillary layer. A relationship between thinning of the choroid and thickening of the pigmented epithelium of the retina was detected.
