Biodistribution of rhenium cluster complex K₄[Re6S8(CN)6] in the body of laboratory rats
K A Brylev1, M A Shestopalov, O P Khripko
1A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences; Innovation Center Vektor, Novosibirsk; Novosibirsk State National Research University, Russia; Soochow University, Waishuanghsi, Shihlin, Taipei, Taiwan. fed@niic.nsc.ru.
Abstract:
We studied the biodistribution of luminescent octahedral rhenium cluster complex K4[Re6S8(CN)6], a promising agent for photodynamic therapy. It was shown that rhenium complex [Re6S8(CN)6](4-)is mainly accumulated in the liver, the central organ of metabolism, and can be excreted by the kidneys. The cluster complex was also accumulated in the spleen in significant amount, which makes it a promising agent for creation of preparations for diagnostics and treatment of lymphoproliferative disorders. The mean lethal dose of the cluster complex was 0.38 g/kg.
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