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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Audit of missed or delayed antimicrobial drugs
1East and South East England Specialist Pharmacy Services.
Abstract:
Although the National Patient Safety Agency published a Rapid Response Report on reducing harm resulting from omitted or delayed medication in 2010, omitted doses continue to occur frequently. The Francis report raised awareness of the problem and its potential impact on care. This article discusses the findings from a multicentre point-incident collaborative audit, focused on antimicrobials. We reviewed records from 6,062 patients prescribed 21,825 doses of antimicrobials; 13% were affected by omitted doses. Some doses are omitted in patients' best interests, but organisations need to identify those that occur for no acceptable reason and target them as a priority. We need national initiatives, strong local nursing leadership and multidisciplinary engagement to support a range of targeted interventions to achieve effective, sustained improvements. The tools developed from this study may help others to begin tackling this issue.
Insights
Omitted medication doses remain a frequent issue despite patient safety reports. A collaborative audit found 13% of antimicrobial doses were omitted, highlighting the need for targeted interventions and leadership to improve patient care.
Area of Science:
- Patient Safety
- Medication Management
- Antimicrobial Stewardship
Background:
- Omitted and delayed medication doses continue to be a significant patient safety concern, despite previous reports and awareness initiatives.
- The Francis report underscored the potential impact of medication errors on patient care, necessitating further investigation into their occurrence.
Purpose of the Study:
- To investigate the incidence and patterns of omitted antimicrobial doses through a multicentre point-incident collaborative audit.
- To identify the extent to which antimicrobial doses are omitted and to inform targeted interventions for improvement.
Main Methods:
- A multicentre point-incident collaborative audit was conducted.
- Patient records for 6,062 individuals, encompassing 21,825 prescribed antimicrobial doses, were reviewed.
Main Results:
- A total of 13% of all prescribed antimicrobial doses were found to be omitted.
- While some omissions may be clinically justified, a significant proportion may occur without acceptable reason, requiring organizational attention.
Conclusions:
- Sustained improvements in medication safety require national initiatives, robust local nursing leadership, and multidisciplinary collaboration.
- The study provides tools and insights that can assist healthcare organizations in addressing omitted medication doses and enhancing patient care.
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