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Brain-derived neurotrophic factor Val66Met polymorphism and cognitive function in persons with cardiovascular disease
Ashley J Szabo1, Michael L Alosco, Lindsay A Miller
1Department of Psychology, Kent State University, Kent, Ohio, USA.
Summary
Brain-derived neurotrophic factor (BDNF) gene variations showed a link to better attention and memory in cardiovascular disease (CVD) patients, though overall impact was minimal. Further research is needed to clarify these cognitive function findings.
Area of Science:
- Neuroscience
- Genetics
- Cardiology
Background:
- Cognitive impairment is prevalent in cardiovascular disease (CVD).
- Genetic factors, such as brain-derived neurotrophic factor (BDNF) gene variations, are potential contributors to cognitive decline in CVD.
- Understanding these genetic influences is crucial for developing targeted interventions.
Purpose of the Study:
- To investigate the association between BDNF genotype and cognitive function in individuals with CVD.
- To determine if specific BDNF gene variations impact different cognitive domains.
Main Methods:
- 110 participants with CVD underwent a comprehensive neuropsychological assessment.
- DNA samples were collected to determine BDNF genotype (methionine allele carriers vs. non-carriers).
- Hierarchical regression analyses were used to examine cognitive performance differences.
Main Results:
- Individuals with at least one BDNF methionine allele showed enhanced attention/executive function and memory compared to valine/valine homozygotes.
- A trend towards better language and visuospatial abilities was observed in methionine allele carriers.
- These findings suggest a nuanced role of BDNF genotype in cognitive performance within the CVD population.
Conclusions:
- The BDNF Val66Met polymorphism had a limited impact on overall cognitive functioning in older adults with CVD.
- The observed cognitive benefits in methionine allele carriers contrasted with some previous research.
- Further studies are recommended to explore the interplay of circulating BDNF levels and genetic variations on long-term cognitive trajectories in CVD.
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