Dietary non-nutritive factors in targeting of regulatory molecules in colorectal cancer: an update

Area of Science:

• Oncology and Cancer Research
• Gastroenterology
• Molecular Biology

Background:

• Colorectal cancer (CRC) is a leading global malignancy, arising from disruptions in intestinal epithelial homeostasis.
• Key molecular pathways implicated in CRC development include iNOS, COX-2, Nrf2, Wnt/β-catenin, Notch, and apoptosis.
• Understanding these pathways is crucial for developing effective prevention and treatment strategies.

Purpose of the Study:

• To review current molecular targets for colon cancer elimination.
• To update knowledge on dietary and non-nutritional compounds for CRC prevention.
• To explore interactions between compounds and regulatory molecules in CRC.

Main Methods:

• Literature review of scientific articles on colorectal cancer targets and compounds.
• Analysis of molecular pathways involved in intestinal epithelial regulation.
• Synthesis of information on dietary and non-nutritional agents impacting CRC.

Main Results:

• Identified several promising molecular targets (iNOS, COX-2, Nrf2, Wnt/β-catenin, Notch, apoptosis) for CRC intervention.
• Highlighted the potential of various dietary and non-nutritional compounds.
• Emphasized the role of these compounds in modulating regulatory molecules to prevent CRC.

Conclusions:

• Targeting specific molecular pathways offers potential for CRC prevention and therapy.
• Dietary and non-nutritional compounds can interact with these pathways.
• Further research into these interactions may lead to novel CRC chemopreventive and therapeutic strategies.