Related Experiment Video
Updated: May 5, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
[Heat stroke related to the use of topiramate. The importance of prevention]
M Rosich Del Cacho1, J Pareja Grande1, M D Martínez Jiménez1
1Servicio de Urgencias Pediátricas, Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
Abstract:
Heat stroke is the most severe pathology related to heat. It is defined as an increase in core body temperature accompanied by signs of neurological dysfunction. In the absence of an early treatment, it has a very high mortality rate. Topiramate is a well known drug widely used in epilepsy treatment and migraine prevention. Oligohydrosis has been described amongst topiramate side effects, favouring the risk of hyperthermia and heatstroke. We present the case of a patient who developed heat stroke due to physical exercise while under topiramate treatment.
Related Concept Videos
Increased Body Temperature
Homeostatic Imbalances in Body Temperature
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Decreased Body Temperature
Increased pulse rate
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
Factors Affecting Body Temperature
Factors may include:

